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Describe an opportunity or threat you have identified in the company ROYAL CARIBBEAN ON THE economic PART. Use at least one type of evidence to support your position and suggest one way the firm could respond to this trend or situation (i.e. recommended course of action). 

  • Includes one hyperlink to supporting evidence or information

CHE300_FA21_Assignment4_15_F2.pdf

Chemical Engineering Department

Assignment 4 (15%)

Semester Spring Year 2022

Course Title Junior Seminar

Course Code CHE300 Section F2

Student Name Student ID

Due Date Refer to Moodle Instructor Dr. Abdullah Nasr

Guidelines for Solution Please read and apply the following points carefully:

1. Your submitted solution can be either typed or handwritten.

2. Write your name and ID# clearly on the submitted file.

3. Provide detailed answers including steps, equations, and units according to question type.

4. For handwritten submissions:

a) Use blue pen

b) Write your name and ID clearly on the first page.

c) Make sure that your answers are very clear and organized.

d) Redraw required tables and graphs whenever applies.

e) If your answers are related to a figure, mention it clearly.

5. Scan the assignment (hard copy) and save it as one pdf file.

6. Submit the pdf (only one file) file through the assignment submission link on your Moodle section

page.

7. You can submit your assignment no more than twice. So, make it count.

8. Students are fully responsible for submitting a correct file. Make sure it is the correct file, it is not corrupted, and it is readable. Unclear or absent answers would be deducted.

9. Inaccurate or corrupted files would result in a deduction as per grading policy.

10. Late submission will be allowed with penalty:

a) Delay by 1 calendar Day – 40% Deduction (grade is multiplied by 0.6)

b) Delay by 2 calendar Days – 60% Deduction (grade is multiplied by 0.4)

c) Delay by 3 calendar Days or more – zero grade. No submission is accepted.

Question 1: [25 points]

In your own words explain what Bribe is and give examples about it. Do you think lobbying or “Wastah” can be a form of bribe? Explain your answer.

Question 2: [10 points]

Explain the meaning of reasonable care attitude toward responsibility and give example.

Question 3. [65 points]

The short article ̀ ` Comparison of four major industrial disasters from the perspective of human error

factor“ describes safety issues of some of the major industrial disasters.

a. List the major safety failures that contributed to “Piper Alpha“ disaster [25 points]

b. What are the major outcomes of this study in terms of industrial accidents cases? [25 points]

c. State two examples related to human factors that contribute to the disaster. [15 points]

The reference is available in your Moodle page

Comparison_of_four_major_industrial_disasters_CHE300.pdf

Comparison of four major industrial disasters from the perspective of human error factor

Doru Costin Darabont*, Daniel Onut Badea , and Alina Trifu

National Research and Development Institute of Occupational Safety “Alexandru Darabont” –

INCDPM, B-dul Ghencea 35A, Bucharest, Romania

Abstract. This paper presents the preliminary findings of a project still in progress at INCDPM regarding” Knowledge transfer partnership and

research development in the assessment and prevention of occupational

risks which may conduct to disaster”. After studying the major industrial

disasters of our times, it become clear that even with technological

advancement, human error is still the major cause of accidents and

incidents. Analysis of human error and their role in accidents is an

important part of developing systematic methods for reliability in the

industry and risk prediction. To obtain data for predictive analysis is

necessary to analyse accidents and incidents to identify its causes in terms

of component failures and human errors. Therefore, a proper understanding

of human factors in the workplace is an important aspect in the prevention

of accidents, and human factors should be considered in any program to

prevent those that are caused by human error. The comparison between

four major industrial disasters (Chernobyl, Bhopal, Deepwater Horizon,

Alpha Piper) was made using Human Factors Analysis and Classification

System (HFACS), a modified version of "Swiss Cheese" model that

describes the levels at which active failures and latent failures/conditions

may occur within complex operations.

1 Introduction

During the industry history a series of devastating accidents with huge costs both

economical and in human lives have happened. Piper Alpha disaster (1988), Bhopal Gas

Plant disaster (1984), Chernobyl Nuclear Power Plant disaster (1986) and BP Deepwater

Horizon Oil Spill disaster (2010) are examples of such accidents. Although these accidents

happened in different places and time they all have in common, according to analyses and

official reports of accident investigations, the role played by human error in triggering the

disaster.

Analysis of human error and their role in accidents is an important part of developing

systematic methods for reliability in the industry and risk prediction. A predictive analysis

requires identifying the accident’s causes in terms of component failures and human errors.

Therefore, a proper understanding of human factors in the workplace is an important aspect

* Corresponding author: [email protected]

© The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/).

MATEC Web of Conferences 305, 00017 (2020) https://doi.org/10.1051/matecconf/202030500017SESAM 2019

in the prevention of accidents. The comparison between four major industrial disasters

(Chernobyl, Bhopal, Deepwater Horizon, Alpha Piper) was made using Human Factors

Analysis and Classification System (HFACS), a modified version of "Swiss Cheese" model

that describes the levels at which active failures and latent failures/conditions may occur

within complex operations and based on official investigation reports.

1.1 Human error factor

The term “human factors” was defined by Gordon in 1998 [1] as the study of the

interactions between human and machine and also includes: management functions,

decision making, learning and communication, training, resource allocation and

organisational culture.

It has been widely acknowledged the role of human actions in major disasters, with

studies concluding that the two types of human error, “active errors” and “latent errors”, are

responsible for approximately 80 per cent of accidents [2]. The effects of active errors are almost immediate and are more likely to be caused by frontline operators (control room

crews, production operators etc.). The “latent errors” are caused by the less-visible

organisational issues (time pressure, understaffing, inadequate equipment and fatigue) that

accumulate over time.

1.2 Human Factors Analysis and Classification System (HFACS)

The methodology used in this paper is a broad human error framework called “The Human

Factors Analysis and Classification System” (HFACS) and it was created to understand the

underlying causal factors that lead to an accident without blaming the individuals involved.

The framework of the analysis uses four levels of deficiencies which lead to accident:

1) Unsafe acts, 2) Pre-conditions for unsafe acts, 3) Unsafe supervision and 4)

Organisational failures. Within each level of HFACS, causal categories were developed to

identify the active and latent failures that occur.

1. The Unsafe Acts level represents the unsafe acts of an operator leading to an

incident/accident and is divided into two categories – errors and violations. Errors are

unintentional behaviours, actions of the operator that fail to carry out the desired outcomes,

and violations (routine violations, exceptional violations) are a wilful disregard of the rules

and regulations.

2. The Preconditions for Unsafe Acts level and the first latent tier, is divided into three

categories: environmental factors, condition of operators and personnel factors.

Environmental factors (physical environment, technological environment) refer to the

physical and technological factors that affect practices, conditions and actions of individual

and which result in human error or an unsafe situation. Condition of operators (adverse

mental state, adverse physiological state, physical/mental limitations) refers to the adverse

mental state, adverse physiological state, and physical/mental limitations factors that affect

practices, conditions or actions of individuals and result in human error or an unsafe

situation. Personnel factors (crew resource management, personal readiness) refer to the

crew resource management and personal readiness factors that affect practices, conditions

or actions of individuals, and result in human error or an unsafe situation.

3. The Unsafe Supervision level deals with performances and decisions of supervisors

and managers that can affect the performance of operators in the frontline and is

categorized into four categories: inadequate supervision (includes those times when

supervision either fails to or provides inappropriate or improper guidance, oversight, and/or

training), plan inappropriate operation (involves those situations when supervisors fail to

evaluate the risk associated with a task, thereby placing employees at an unacceptable level

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of risk; these include improper staffing, mission not in accordance with rules/regulations,

and inadequate opportunity for crew rest), fail to correct known problem (refers to those

instances where unacceptable conditions of equipment, training or behaviours are

identified, yet actions or conditions remain uncorrected, meaning supervisors fail to initiate

corrective actions or report such unsafe situations), supervisory violation (the wilful

disregard of the established rules and regulations by those in positions of leadership).

4. The Organisational Influences level, and the final latent tier, is divided into three

categories: resource management (includes top management decisions related to the

allocation of such resources as equipment, facilities, money, and personnel), organisational

climate (refers to those variables, such as the organizational structure, culture, and policies,

which affect worker performance), organizational process (refers to the decision-making

that governs the day-to-day operations of an organization, such as operations, procedures,

and oversight).

2 Major industrial disasters

2.1 Chernobyl

2.1.1 Short description of the accident

On April 26,1986, the Chernobyl Nuclear Power Plant in Ukraine exploded, creating what

was considered the worst nuclear disaster the world has ever seen. The Chernobyl plant

used four Soviet-designed RBMK-1000 nuclear reactors — a design that's now universally

recognized as inherently flawed. RBMK reactors were of a pressure tube design that used

an enriched U-235 uranium dioxide fuel to heat water, creating steam that drives the

reactors' turbines and generates electricity. The accident occurred during a test executed

before the unit shutdown for the planned maintenance. The test aimed to study the

possibility of utilization of the mechanical energy of a turbo-generator after cut-off of steam

supply, practically to check the possibility of powering the main reactor coolant pumps

from one of the turbo-generators for a few seconds while it was slowing down under its

inertia in the event of loss of offsite power, thereby providing additional time for

emergency takeover by the diesel generators. This test was performed neither under the

planned conditions nor in compliance with reactor operating procedures. In particular,

several safety systems were disabled [3]. According to the Soviet experts the prime cause of

the accident at the Chernobyl nuclear power plant was “…an extremely improbable

combination of violations of instructions and operating rules committed by the staff of the

unit”. This conclusion sets a full responsibility for the accident at the Chernobyl on its stuff.

2.1.2 Contributory factors of accident distributed according to HFACS’ levels

Organizational Influences

1. Training of personal was insufficient and totally inconsistent with absence of passive

safety features in the reactor design. Not knowing much about the behaviour of the reactor

core, they were unable to appreciate the implications of the decisions they were making,

and their situation was even more dangerous in that the test was being done at low power

and in violation of standing orders. 2. Safety procedures not in place. 3. The culture of

secrecy, imposed compartmentalization of knowledge: no single person was allowed to see

the big picture and to integrate all aspects of the safety of the operation. 4. Political issues.

The scientists and engineers worked under one guideline: to produce plutonium – as much

as possible and as quickly as possible.

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Unsafe Supervision

1. The operating instructions, both the standing orders and the specific instructions for the

test, were incomplete and imprecise. 2. Bad communication not only between the operators,

but also with authorities and government.

Preconditions for Unsafe Acts

1. A flaw in the reactor design that makes the RBMK reactor core is unstable below 700

Megawatts-thermal, about a quarter of full power, meaning that at low power the reactor is

difficult to control and any tendency toward a runaway chain reaction is automatically and

rapidly amplified. 2. The insertion of the control rods is too slow, taking about 20 seconds

to full insertion while it takes less than 2 seconds in other reactors throughout the world.

This is much too slow to prevent runaway of the core while it is operating in the unstable

mode. 3. Lack of emergency control rods with fast insertion. The tips of control rods, when

inserted, first increase the reactivity. 4. No safeguards that controls the number of rods.

Unsafe Acts Operation

1. The number of reserve control rods in the reactor core was drop below permissible

levels, 2. The automatic controls for the reactor's power level were shut off, 3. Both the

main water-circulation pumps and the backup pumps were turned on at the same time,

forcing the coolant to flow too quickly, 4. Cutting off automatic blocking devices that

would have shut off the reactor when steam failed to reach the generator, 5. Switching off

systems that controlled water level and steam pressure, 6. Turning off “the most sacred

thing” – the emergency safety cooling system for the reactor.

2.2 Bhopal

2.2.1 Short description of the accident

Bhopal accident was the spillage of a very toxic substance – methyl isocyanate (MIC) – to

the atmosphere in large quantities from a pesticide plant. It led to the dead of more than

5000 people. The methyl isocyanate (MIC) was stored in three underground tanks made of

stainless steel that have to be kept refrigerated so that the temperature of content to be close

to 0°C. To prevent release of methyl isocyanate in the atmosphere, after the tank there was

a vent gas scrubber that would neutralize the MIC by spraying alkali. Also, then there was a

flare tower to burn the remaining gases going from the vent gas scrubber. The plant was

shut down for maintenance two months prior to the accident. Due to a series of errors, lack

of knowledge and delays in response of operators and supervisors 40 to 45 tonnes of MIC

escaped, part of which got decomposed into hydrogen cyanide.

At 2,30 in the morning MIC vapours started affecting people in the vicinity, and a large

number of people started running out of the houses. On the morning of 3 December, the

local hospital had about 12000 persons. Again on the night of 3/4 December, MIC from the

atmosphere recondensed and more people were affected. On the 4 December 1984 Hamidia

Hospital had to handle about 55000 people [4].

2.2.2 Contributory factors of accident distributed according to HFACS’ levels

Organizational Influences: 1. Carrying out plant modifications in hazardous facilities

without hazard and operability studies; 2. Storing 55 tonnes of MIC while usage daily was

5 tonnes; 3. Neglecting safety management at the unit; 4. No action on earlier accident

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MATEC Web of Conferences 305, 00017 (2020) https://doi.org/10.1051/matecconf/202030500017SESAM 2019

analysis reports; 5. Heavy reliance on inexperienced operators; 6. decision to reduce

operating and maintenance staff in control room/plant;

Unsafe Supervision: 1. using a non-trained superintendent for the plant; 2. failure to

recognize that the pressure rise was something abnormal; 3. failure to use the empty MIC

tank to release the pressure.

Preconditions for Unsafe Acts: 1. Refrigeration plant was not operational; 2. pressure

indicator and temperature indicator not working; 3. flare tower was disconnected; 4. vent

gas scrubber not in active mode; 5. plant modification; 6. use of iron pipelines for MIC; 7.

no indicator for monitoring position of valves in control room.

Unsafe Acts: 1. Repressurizing the tank when it failed to get pressurized once; 2. failure

of shift operator to communicate information on pressure increase to the next operator; 3. issuing orders for washing when methyl isocyanate tank failed to get pressurize; 4. not

following the safety precautions while washing MIC lines; 5. failure to recognize the

seriousness of the leak; 6. failure to inform Works Manager as soon as the leak started.

2.3 Deepwater Horizon

2.3.1 Short description of the accident

Deepwater Horizon was an ultra-deep water, dynamically positioned, semi-submersible

offshore drilling rig owned by Transocean and leased to British Petroleum. On 20 April 2010, while drilling at the Macondo Prospect, an uncontrollable blowout caused an

explosion on the rig that killed 11 crewmen and ignited a fireball visible from 64 km away.

The fire was inextinguishable and, two days later, on 22 April, the Horizon sank, leaving

the well gushing at the seabed and causing the largest oil spill in U.S. waters. Every one of

the Deepwater Horizon’s many defences failed—some were never engaged, some were

engaged too late, and some simply did not work as designed. The chain of events between

February and the disaster could have been interrupted at many points, but a lack of

preparation and experience and an unclear chain of command prevented key decisions at

every step [5].

2.3.2 Contributory factors of accident distributed according to HFACS’ levels

Organizational Influences: 1. Decision to proceed to temporary abandonment of the

exploratory well, 2. Changing key supervisory personnel on the Deepwater Horizon just

prior to critical temporary abandonment procedures, 3. Time pressure, 4. Communication

was poor among and between rig crew members who worked for multiple companies and

shore superiors and middle and top management, 5. Financial pressures to complete the

operation quickly, 6. Lack of sufficient training.

Unsafe Supervision: 1. Oversimplified instructions, 2. Last minute changes in procedures,

3. Last minute changes of personnel, 4. Insufficient experience

Preconditions for Unsafe Acts: 1. The Macondo prospect presented a number of technical

challenges from the start, such as deep water, high formation pressures and temperatures,

and the need to drill through multiple geologic zones. 2. Valve failure, allowing oil and gas

to travel up the pipe towards the surface. 3. Leak not spotted soon enough – whether a well

is under control or not, the crew at the surface should be able to detect a flow of oil and gas

towards the surface by looking for unexpected increases in pressure in the well. 4. No

battery for blowout preventer – the explosion destroyed the control lines the crew were

using to attempt to close safety valves in the blowout preventer.

Unsafe Acts or Operation: 1. Attempting to cement the multiple hydrocarbon and brine

zones encountered in the deepest part of the well in a single operational step, despite the

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MATEC Web of Conferences 305, 00017 (2020) https://doi.org/10.1051/matecconf/202030500017SESAM 2019

fact that these zones had markedly different fluid pressures. 2. Using the wrong cement

formula – The cement at the bottom of the borehole did not create a seal, and oil and gas

began to leak through it into the pipe leading to the surface. 3. Overwhelmed separator –

The crew had the option of diverting the mud and gas away from the rig, venting it safely

through pipes over the side. Instead, the flow was diverted to a device on board the rig

designed to separate small amounts of gas from a flow of mud. 4. Pressure test

misinterpreted – The crew carried out various pressure tests to determine whether the well

was sealed or not. The results of these tests were misinterpreted, so they thought the well

was under control. 5. Failure to observe and respond to critical indicators.

2.4 Piper Alpha

2.4.1 Short description of the accident

The Piper Alpha disaster happened on July 6, 1988. In the explosion and subsequent fire on

the oil platform, 167 workers died, while only 61 survived. The death toll was the highest

of any accident in the history of offshore operations. The Piper Alpha rig, started initially in

1976 with oil production, being converted to gas recovery in 1980. Unfortunately, this

repurposing was poorly made from the point of view of safety (for example, the gas

compression units were installed next to the central control room) and wherein lies one of

the causes of the disaster. The series of constructions, maintenance and upgrade works

diluted the safety features of the four modules of Piper Alpha which were initially separated

by firewalls with the most dangerous operations distant from the personnel areas. A lack of

communication between operators causes to operate a pump being under maintenance and

having a safety valve dismantled. As a result, an important gas leakage occurred. Although

six gas alarms were triggered the gas ignited before anyone could act. Further compromises

in the safety system were facilitated by further explosions resulting in the gas line melting,

which released 15-30 tonnes of gas every second into the fire. The fire was soon being fed

by oil from two separate rigs that shared a communal oil pipe. When the platform blew out

167 of 228 workers died. The platform was completely destroyed and it took almost three

weeks for the fire to be brought under control [6].

2.4.2 Contributory factors of accident distributed according to HFACS’ levels

Organizational Influences: 1. The decision of owners to keep the platform producing oil

and gas as it set about a series of construction, maintenance and upgrade works; 2. Lack of

training; safety procedures not in place; 3. Insufficient number of crew members.

Unsafe Supervision: 1. Communication breakdown for permit to work PTW; 2. Shift

change procedure not properly functioned.

Preconditions for Unsafe Acts: 1. Improper restructuring of platform – the gas compression

units were installed next to the central control room; 2. Improper installation of pressure

safety valves; 3. Undetected gas release

Unsafe Acts Operation: 1. Placing a vital document in the wrong place; 2.Restarting of a

pump in maintenance; 3.Command system failed in emergency.

3 Results and discussions

Table 1 presents a synthesis of the contributory factors of the above analysed accidents. The

results indicate that 50% of the contributing factors identified in each of the four accidents

reviewed are latent failure in level 2 and level 4. There are environmental factors,

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MATEC Web of Conferences 305, 00017 (2020) https://doi.org/10.1051/matecconf/202030500017SESAM 2019

conditions of the operator, personnel factors, resource/acquisition management,

organizational climate, and organizational process that shows that is possible for the

failures created at higher level to remain in the system for a considerable time without

being noticed, thereby creating conditions for accidents to occur during operations.

Table 1. Contributory factors of the analysed accidents

Level of HFACS Accidents

Piper Alpha Chernobyl Deepwater Bhopal

Level 4. Organizational

Influences 3 4 5 8

Level 3. Unsafe

Supervision 3 2 4 3

Level 2. Preconditions

for Unsafe Acts 3 4 4 7

Level 1. Unsafe Acts 3 6 5 6

4 Conclusions

After studying the major industrial disasters of our times, it become clear that even with

technological advancement, human error is still the major cause of accidents and incidents.

Analysis of human error and their role in accidents is an important part of developing

systematic methods for reliability in the industry and risk prediction. To obtain data for

predictive analysis is necessary to analyse accidents and incidents to identify its causes in

terms of component failures and human errors. Therefore, a proper understanding of human

factors in the workplace is an important aspect in the prevention of accidents, and human

factors should be considered in any program to prevent those that are caused by human

error.

Also, the comparison between four major industrial disasters made in this paper

indicates that 50% of the contributing factors identified in each of the four accidents

reviewed are latent failure in level 2 and level 4. There are environmental factors,

conditions of the operator, personnel factors, resource/acquisition management,

organizational climate, and organizational process that shows that is possible for the

failures created at higher level to remain in the system for a considerable time without

being noticed, thereby creating conditions for accidents to occur during operations and

supports the view that all human initiated disasters ultimately can be traced back to

deficiencies in the management of the systems at the corporate level. Yet in major accident

assessment and prevention, these deficiencies are often overlooked or very inadequately

addressed.

References

1. R. Gordon The contribution of human factors to accidents in the offshore oil industry, J Reliability Engineering and System Safety 61 (1998) 95-108

2. A. Aas, The human factors assessment and classification system (HFACS) for the oil & gas industry. Paper presented at the International Petroleum Technology Conference (2008).

3. INSAG-7 The Chernobyl Accident. A report by the International Nuclear Safety Advisory Group, International Atomic Energy Agency Vienna, 1992

4. Delhi Science Forum Report: Bhopal Gas Tragedy, J Social Scientist, 13, 32-53, (1985) 5. U.S. Chemical Safety and Hazard Investigation Board Investigation report vol 3, Drilling rig

explosion and fire at the Macondo well, Report no. 2010-10-i-os, (2016)

6. Departament of Energy, The public Inquiry into the Piper Alpha Disaster, vol 1, November 1990

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MATEC Web of Conferences 305, 00017 (2020) https://doi.org/10.1051/matecconf/202030500017SESAM 2019

Reply 1 and 2 by 04/15/2022 at 6 pm, please add references and citations

Reply 1

 amilka Zulueta posted Apr 12, 2022 1:11 PMSubscribe

a) The Pharmacological Therapies Prescription for Jonathan

Jonathan is a patient who has been a frequent visitor to the clinic with a healthy report save for a history of mild asthma. The treatment of the patient major clinical symptoms of cough wheezing will rely on the patient history with the suspected asthma clinical manifestations. The respiratory abnormality of the lung will need to be solved using medication that can clear the respiratory tract to make breathing easier. The corticosteroid can be used as a respiratory tract medication that is used to ease breathing, reduce airways inflammation and manage cough from asthmatic attack (Maselli, & Peters, 2018). The type of corticosteroid that will be ideal for Jonathan is Flunisolide dosage of a spry on the nostril with the need to monitor the breathing pattern of the child. 

b) The Necessary Information to Be Provided to Johnathan and His Mother Regarding Asthma Exacerbation

The information about asthma needs to be provided to the duo on preventable measures and management of the asthma exacerbation preventing the damage to the respiratory system. The patient needs to avoid smoking both as a first user and a secondary consumer to limit the respiratory tract risk and other related allergens that are part of the environment such as cold, animal dander, and dust. The management of the asthma exacerbation will also need the right use of the prescribed medication taking the doses as advised. The self-administer Corticosteroid needs to be illustrated to the 7-years-old on how to use it and how to keep it safe from other children. The mother will need to show emotional support to the patient. 

c)The Appropriate Clinical Assessment Tool to Be Use with Johnathan

The asthmatic clinical assessment is part of the patient care that will be formulated with the effort of the patient to keep records about the management of the symptoms. The available clinical assessment that will best for Jonathans asthma control is the Childhood Asthma Control Test with a scale of up to 5 used in identifying the symptoms and management findings. The Childhood Asthma Control Test has a questionnaire calibration of the asthma control for children with frequent asthma exacerbation which can be used for children and adolescent patients (Tosca et al., 2021). The parent will need to be guided on how to use the Childhood Asthma Control Test for a clear understanding of the asthma control and management achieved at home.

d)The Classification of Asthma

According to Plaza et al., (2021), the classification of asthma can be categorized according to the manifestation of the illness, the medication needs, the effect of the illness on the functions of the lungs, and the symptoms interference with the activities of the patients as classified below;

Intermittent Stage. The first stage with no major symptoms can easily be managed with the rare use of the rescue inhaler. There is more than 80% FEV1/FVC which institutes a normal functioning of the lungs and two days or less indication of symptoms in a week.

  1. Mild persistent

The illness at this stage is still controllable with the normal activities of the patients reported. The patient can experience minimal nighttime symptoms with rare 3 times in a month having normal functions of the lung during breathing out and breathing in.

  1. Moderate persistent.

 This is where more patient care is required with the interference with the functions of the lungs showing the hindrance to the school or work activities. There will be rampant nighttime symptoms more than twice a week but not daily. The patient will be needed to have a rescue inhaler with them for any emergency.

  1. Severe persistent. 

At severe persistent, the lung is affected with the struggling functionality with the serious symptoms. The management of the symptoms cannot be done by the patient with the need of the healthcare specialist to develop a combination of medications that can clear the lungs’ airways.

e) The Mothers Concern Regarding Providing an Inhaler at School as The NP

The use of an inhaler needs the analysis and the review of environmental such as exposure to the allergens such as smoke, classification of asthma, and exercise tolerance in managing the pulmonary functions (Kilbride et al., 2019). The analysis of the patient will support the use of a rescue inhaler in school as though the patient has a history of mild asthma he has reported wheezing and coughing for the last 24 hours plus and the environment as a young student who may need exercise tolerance inhaler in school to be used before engaging in exercise as he will probably need to play with other students.

f) The Appropriate Plan of Care for Johnathan

The necessary patient care plan for asthmatic patients should take care of breathing patterns, airways clearance, deficient knowledge, anxiety, and activity intolerance (Hancox et al., 2021). The guidance that will be suitable for Johnathan will be inclusive of self-care education on how and when to take the medication prescribed, avoiding airway blockage risks such as smoke and dust, and management of activity intolerance. There will also need parent and teacher efforts in managing illness anxiety supporting the patient during the treatment journey mentally and socially among the peers.

                                                        References

Hancox, R. J., Jones, S., Baggott, C., Chen, D., Corna, N., Davies, C., … & Young, R. (2021). New Zealand COPD Guidelines: Quick Reference Guide. The New Zealand Medical Journal (Online), 134(1530), 76-110.

Kilbride, H., Escobar, H., Holmes, A., Teson, K., & Truog, W. (2019). Childhood pulmonary function, exercise capacity, and exhaled nitric oxide levels: outcomes following neonatal treatment with inhaled nitric oxide to prevent bronchopulmonary dysplasia. American journal of perinatology, 36(04), 360-365. DOI: 10.1055/s-0038-1668556

Maselli, D. J., & Peters, J. I. (2018). Medication regimens for managing acute asthma. Respiratory Care, 63(6), 783-796. 

Plaza, V., Alobid, I., Alvarez, C., Blanco, M., Ferreira, J., Garca, G., … & Sanz, J. (2021). Spanish Asthma Management Guidelines (GEMA) v. 5.1. Highlights and Controversies. Archivos de Bronconeumologa (English Edition). 

Tosca, M. A., Marseglia, G. L., & Ciprandi, G. (2021). The Real-World Controlasma Study: a nationwide taskforce on asthma control in children and adolescents. Allergologia et Immunopathologia, 49(1), 32-39.

Reply 2 

 Norma Boone posted Apr 13, 2022 10:28 PMLast edited: Thursday, April 14, 2022 5:30 AM MDTSubscribe

What are the appropriate pharmacological therapies to be prescribed for Johnathan?

A classic characteristic of asthma is airway hyperresponsiveness which includes the clinical symptoms of wheezing, chest tightness and dyspnea (Woo, 2019). Clinical symptoms of asthma appear after exposure to stimuli from allergens and environmental irritants such as air pollution, dust mites, mold, cockroach antigen, and tobacco smoke (Brashers & Rote, 2019). Additional risk factors for asthma include viral respiratory tract infections, exercise, cold air, gastroesophageal reflux, preterm birth, and childhood obesity (Brashers & Rote, 2019, Woo, 2019). Jonathan has a recent history of having an upper air infection at which time he started experiencing wheezing. He presents for his doctor appointment with diffused expiratory wheezing and mild retractions. According to Woo (2019) “children with persistent asthma require daily anti-inflammatory therapy” (p. 363). The Global Initiative for Asthma (GINA) provides guidelines to assist healthcare providers in the pharmacological management of asthma through step therapy (Woo, 2019). Step 2 therapy suggest that mild persistent asthma in young children should be treated with a low-dose inhaled corticosteroid (via nebulizer or MDI and mask), coupled with leukotriene modifier. The treatment prescribed for Jonathan will be a low dose generic corticosteroid nebulizer solution of 0.5mg daily with montelukast chewable tablet 5mg at bedtime. In addition, Jonathan will continue with the use of his Albuterol inhaler. GINA guidelines recommend that patients suffering from mild intermittent asthma should continue to use their short acting beta2 antagonist bronchodilator (Woo, 2019). Continued use of the SABA enables the patient to feel in control of their asthma. Although Jonathan is being prescribed two new medications for his asthma, both are once a day dosage. Healthcare providers must be cognizant when adding medications to a patient’s medication regimen, prescribing combination medications facilitates medication compliance.

What information is necessary to provide to Johnathan and his mother regarding asthma exacerbation?

Asthma exacerbation is classified as mild, moderate, severe, or life threatening. An essential component of asthma therapy is to achieve long-term control by reducing episodes of impairment and risk (Brashers & Rote, 2019). The first step is to educate Jonathan and his mother on allergen avoidance. In addition, early treatment, which starts at home, is an essential strategy for managing and reducing episodes of asthma exacerbation. Teaching Jonathan and his mother the signs and symptoms to monitor for and to take immediate action is critical in the success of managing his asthma. Providing Jonathan and his mother with a written asthma action plan and appropriate medications is another critical part of his asthma exacerbation management plan. Castillo, Peters, and Busse (2017) discussed the use of a home treatment plan that consist of four components to reduce or prevent emergency room visits and or hospitalizations. The home management of asthma exacerbation plan includes written for monitoring of symptoms and lung function, criteria based on symptoms that trigger action, and two or three actions points that include written instructions on the use of inhaled or oral corticosteroids (Castillo et al., 2017).

What is an appropriate clinical assessment tool to be use with Johnathan?

Woo (2019) discussed the importance of monitoring lung function to determine normal airway function. GINA recommends the use of spirometry after initial treatment for asthma exacerbation and at 3 to 6 months as follow-up (Woo, 2019). GINA also recommends the use of a home peak flow meter to monitor lung function in patients who are classified as moderate to severe. Utilizing a peak flow meter to monitor PEF readings help detect early changes in asthma status, evaluate response to changes in medication therapy, and provide a quantitative measure of airflow obstruction. However, GINA does not recommend long term monitoring with a home peak flow meter for asthmatics classified as mild intermittent or mild persistent (Woo, 2019).

What are the classification of asthma?

Asthma severity is determined by evaluating an asthmatic patient who has achieved control of their asthma after being on asthma control medication for several months along with step-down treatment therapy (Woo, 2019). There are three classifications of asthma: mild, moderate, and severe. For purposes of the patient presented in this case study, Jonathan, will hopefully be classified as mild. His treatment plan was selected from the step one and step two treatment choices which consist of a short-acting reliever, a leukotriene modifier, and a low/medium dose corticosteroid).

How would you as the NP address his mother’s concern regarding providing an inhaler at school?

Addressing concerns of patients as well as their caregivers in a caring and authentic manner is paramount in building trusting provider-client relationships. In the case of Jonathan, inquiring from the mother whether his school has policies on self-administration of rescue inhalers is important. The 2005 National Association of School Nurses (NASN) position statement argued that “for the majority of children with asthma, proper monitoring and management ensures that the child is able to participate in normal, everyday activities. Rescue inhalers are prescribed medications that act rapidly upon the airway to relieve shortness of breath and compromised respiratory status. Timely and rapid administration of the rescue inhaler can be crucial for a student with asthma. Because children spend a good portion of their day in the school setting, students must have appropriate access to rescue medication to control asthma at school. The NASN (2017) position statement addressed the need and responsibility of school nurses to develop individualized healthcare plans for students who may have risk for physical and mental health needs. In addition, providing resources that provide education for the child as well as the parent is essential for compliance and control of illnesses and disease. The CDC  (2020) offers variety educational information on the treatment of asthma and school age children, including videos that demonstrate the proper techniques in administering inhaler when self-administered by children. Having the proper resources is essential for Jonathan’s mother to make informed decisions about his health and control of his asthma.

What is an appropriate plan of care for Johnathan?

An appropriate plan of care for Johnathan includes both pharmacologic therapy and non-

pharmacological management. A review of medications, technique, and adherence are covered

at this visit and during each follow-up session. Asthma therapy is guided by the necessity to

control episodes of exacerbation; therefore, a detailed individualized asthma care plan providing appropriate medications is critical to a home management plan. The four components included in the home management plan reduce and prevent emergency room visits and or hospitalizations (Castillo et al., 2017). Inhaled corticosteroids (ICSs) are the most effective long-term control therapy, combined with short-acting beta agonists, such as Albuterol. Achieving and maintaining appropriate asthma control requires providing uncomplicated and appropriate medication regimen, addressing environmental factors that cause worsening symptoms, helping patients learn self-management skills, and monitoring over the long term to assess control and adjust therapy accordingly. Johnathan should also be instructed on proper hand-hygiene which facilitates the prevention of unwanted viral or bacterial illnesses.

Reference

Brasher, V. L. & Huether, S. E. (2019). Alterations of pulmonary function in children. In V. L. Brashers & N. S. Rote (Eds.). Pathophysiology the biologic basis for disease in adults and children (pp. 1202-1227). St. Louis Missouri: Elsevier.

Castillo, J. R., Peters, S. P., & Busse, W. W. (2017). Asthma Exacerbations: Pathogenesis, Prevention, and Treatment. The journal of allergy and clinical immunology. In practice5(4), 918927.

Centers for Disease Control and Prevention. (2020). Asthma: School and Childcare Providers. Retrieved from httsp://www.cdc.gov/asthma/school.html

National Association of School Nurses. (2017). Position Statement: Use of Individualized Healthcare Plans to Support School Health Services. Retrieved from

National Association of School Nurses. (2005). Position Statement: The Use of Asthma Rescue Inhalers in the School Setting. Retrieved from https://www.files.nwesd.org/website/

Woo, T. M. (2019). Pharmacotherapeutics for Advanced Practice Nurse Prescribers with 3-yr access to Davis Edge (5th Edition). F. A. Davis Company. https://digitalbookshelf.southuniversity.edu/books/9781719641531

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Describe an opportunity or threat you have identified in the company ROYAL CARIBBEAN ON THE POLITICAL/LEGAL PART. Use at least one type of evidence to support your position and suggest one way the firm could respond to this trend or situation (i.e. recommended course of action). 

  • Includes one hyperlink to supporting evidence or information

examining texts brochure

GRADE LEVEL AND CONTENT AREA TO BE USED:
8TH GRADE HISTORY

Involving families and communities in the classroom learning will improve both student engagement and outcomes. One of the ways that families and communities can be involved in students learning is to inform them of the importance of various texts that support literacy development and how they can support learning at home.

****Create a brochure to be introduced at curriculum night to promote literacy in the home and serve as a resource for families, informing them of the different texts and writing materials that will be implemented as part of the class curriculum.****

***Your brochure should include the process of examining texts and writing strategies, and describe at-home technology tools and digital resources that can be used to advance student literacy development.

********Include the following:**********

**Engaging front cover that identifies the grade level and content area
The importance of multiple texts to meet the specific needs and abilities of all students
**Examples of two different types of texts that will be used in the class with brief rationales describing the complexity and purpose for each as well as the grouping techniques (whole group, independent, small group) that will be used with each selection.
**Explanation of how texts are selected for the classroom through both quantitative and qualitative measures
**An example of how writing will be incorporated into the content area
**Two activities families can do at home to help struggling readers and writers (one activity for reading and one activity for writing)
**Two digital tools or resources families can use to support literacy development at home. **Include one for reading and one for writing as well as brief directions on how to use the tools, or where the families can go to learn how to use them.
****The brochure should be visually appealing with color, graphic elements, and variations in text.

**Support your brochure with a minimum of three scholarly resources.

NSG6005_PharmManagementProjectExemplar_Template_2021v1.pptx

Pharmacological Management Project

Student Name

NSG6005

Faculty name

Pathophysiology of assigned disease

Assigned Disease: Primary Biliary Cholangitis

Pathophysiology: Primary biliary cholangitis (PBC, formerly known as primary biliary cirrhosis) is an uncommon cholestatic liver disease characterized by immune-mediated destruction of biliary epithelial cells. PBC is female preponderant and typically presents in the fifth or sixth decade of life. The clinical presentation may include generalized pruritus, dryness of eyes and mouth, fatigue, and upper abdominal discomfort; patients may be asymptomatic. Typical laboratory findings are elevations in serum alkaline phosphatase levels, increased serum immunoglobulin M levels, and the presence of antimitochondrial antibodies or specific subtypes of antinuclear antibodies. A diagnosis of PBC is usually made without histologic examination. When used, liver biopsy typically reveals nonsuppurative granulomatous cholangitis with loss of small bile ducts and lymphocytic portal inflammation. Patients who do not achieve an adequate biochemical response to first-line therapy have a greater risk of disease progression to cirrhosis and may ultimately require liver transplantation.

Definition of the two assigned drugClassifications

Classification 1: Bile Acid Analog

Bile acids aid in the digestion and solubilization of lipophilic nutrients and drugs in the small intestine, they signal endocrine molecules that regulate the glucose, lipid, and energy metabolism through complex and intertwined pathways that are largely mediated by activation of nuclear receptor farnesoid X receptor (FXR) and cell surface G protein-coupled receptor 1, TGR5 (also known as GPBAR1).

Classification 2: Immunomodulatory therapy

Immunomodulatory drugs modify the response of the immune system by increasing (immunostimulators) or decreasing (immunosuppressives) the production of serum antibodies. Immunostimulators are prescribed to enhance the immune response against infectious diseases, tumours, primary or secondary immunodeficiency, and alterations in antibody transfer, among others. Immunosuppressive drugs are used to reduce the immune response against transplanted organs and to treat autoimmune diseases.

Discussion of 4 medications – 2 from each drug classification(you are to choose the drugs – they must belong to the drug class)

Classification 1: Bile Acid analog

Drug 1: Actigall (ursodiol)

13 – 15 mg/kg/day orally given in 2 – 4 divided doses

Give with food

Drug 2: Obeticholic acid

5 – 10 mg PO qD

Start 5mg PO qd x 3 months, then may increase to 10mg PO qd if needed

Classification 1: immunomodulatory therapy

Drug 1: prednisone

20 – 30 mg PO qd initially for one month, titrate downward according to IgG concentration

Drug 2: Mycophenolate mofetil

500 – 1000 mg PO qd BID

Pharmacokinetics, Pharmacodynamics, safety/monitoring & pregnancy/lactation of the 4 Medications you discussed earlier

Drug 1: actigall (ursodiol)

Metabolism: Liver, GI Tract, CYP450; half-life unknown

Excretion: feces primarily; urine

Mechanism of Action: decreases cholesterol synthesis, secretion, and absorption; alters bile cholesterol composition

Monitoring Parameters: liver function tests q months x 3months, then q6 months

Pregnancy: may use during pregnancy; no known risk of fetal harm based on human data

Lactation: may use while breastfeeding; no known risk of infant harm based on limited human data

Drug 1: obeticholic

Metabolism: live; no CYP450; enterohepatically recirculated; active metabolites

Excretion: feces 87%; urine <3%; half-life 24 hours

Mechanism of Action: agonizes farnesoid X receptor, decreasing intracellular hepatocyte concentrations of bile acids

Monitoring Parameters: liver function tests at baseline, then frequently, especially if there is an increase in risk of hepatic decompensation or before dose adjustment; lipid panel

Pregnancy: caution advised during pregnancy; inadequate human data available to assess risk

Lactation: caution advised while breastfeeding; no human data available to assess risk of infant harm or effects on milk production

Drug 1: prednisone

Metabolism: liver; CYP450 – 3A4 substrate; prodrug converted to prednisolone

Excretion: urine; half-life: 2-4 hours (plasma); 18-36 hours (biological)

Mechanism of Action: exact mechanism of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects

Monitoring Parameters: electrolytes; BP; weight; 2 hours postprandial glucose; chest x-ray if prolonged treatment; ophthalmic exam if treatment >6weeks

Pregnancy: weight risk/benefit during pregnancy, especially in 1st trimester; risk of orofacial cleft based on limited human data; possible risk of teratogenicity based on animal data

Lactation: may use while breastfeeding, consider breastfeeding at least 4 hours after high-dose prednisone use; no known risk of infant harm

Drug 1: mycophenolate mofetil

Metabolism: liver; CYP450-unknown; UGT: 1A9 substrate; info: prodrug converted to mycophenolic acid

Excretion: urine 93%, feces 6%, half-life: 17.9 hour (PO route), 16.6h (IV route)

Mechanism of Action: inhibits B- and T-lymphocyte proliferation

Monitoring Parameters: pregnancy test immediately prior to treatment start, then 8-10 days later, then continue at routine visits, creatinine at baseline, CBC qwk x 1 month, then 2x/mo x 2mo, then q month during 1st year of treatment

Pregnancy: avoid use during pregnancy; risk of fetal harm; included teratogenicity and spontaneous abortion, based on human data

Lactation: weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm though possible drug excretion into milk

Contraindications of the 4 medications discussed earlier

Actigall (ursodiol)

Hypersensitivity to drug, unremitting acute cholecystitis, acute cholangitis, biliary obstruction, gallstone pancreatitis

Obeticholic acid

Hypersensitivity to drug; complete biliary obstruction, caution if Child-Pugh Class B or C hepatic impairment, caution if prior hepatic decompensation event

prednisone

Systemic fungal infection, cerebral malaria, avoid abrupt withdrawal, caution in pediatrics, pregnancy, if immunosuppressed, if active infection, if TB infection, if hypertensive, if diabetic

Mycophenolate mofetil

Hypersensitivity to polysorbate 80, pregnancy, avoid donating blood during treatment and 6 weeks after d/c, avoid semen donation during treatment and 90 days after d/c, caution HBV or HCV infection, caution if CrCl <50

conclusion

Summarize what you learned on this slide – what are the important things to know about the disease, the classifications, drugs and risks

references

Include all the references used following the APA 7th Edition

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 4. Describe the specific strategy (ies) that helped your group members achieve winning net profits and product satisfactions in the game. What specific changes would you make if you did not have the pressure of a grade attached to your choices?  Be specific and Use the concepts from the course to explain. 

 The words “I” and “Me” are not permitted 

SO THIS IS ABOUT A GAME CALLED “MINI SIM” WHERE YOU CREATE A  BACKPACK FOR SELL FOR DIFFERENT PEOPLE LIKE UNIVERISTY STUDENTS, SCHOOL CHILDREN, URBAN OUTFITTERS, AND YOU ALWAYS USE THE 5 P’S ( PRODUCT, PRICE, PLACE, PROMOTION, AND PEOPLE) SO I SET A PRICE FOR THE BACKBACK, I DESIGN IT, AND I PUT EVERYTHING I WANT THAT WILL BE GOOD FOR THE PEOPLE I USED TO SELL IT, SO IF IT WAS FOR UNIVERISTY STUDENTS AND THEY LIKE MORE A COMFORT BACKBACK OR ECOLOGIC, I PUT THE FEATURES THAT THEY LIKE MOST FOR THEY CAN BUY IT AND ALSO USED THE 5 PS. SO YOU HAVE TO CHOOSE WELL TO REACH THE NET PROFIT AND THE PRODUCT SATISFACTION. 

Grace Hopper Celebrating

Tell us why you want to attend GHC. What type of impact will being at a celebration focused on women in computer science have on you? (200 words)

How will you share your experience at GHC with other? What type of Impact will your experience at GHC have on others in your community? (200 words)

Grace Hopper Celebrating

Tell us why you want to attend GHC. What type of impact will being at a celebration focused on women in computer science have on you? (200 words)

How will you share your experience at GHC with other? What type of Impact will your experience at GHC have on others in your community? (200 words)

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